
Poster Presentations
Files
Download PDF of poster (1.2 MB)
Description
Pseudomonas aeruginosa (P. aer.) is the most common cause of ventilator associated pneumonia (VAP) in ICU patients. Different combinations of exoenzymes (S, T, Y, and U) are found in P. aer. strains. ExoY is most often associated with VAP in ICU patients. ExoY infection of pulmonary microvascular endothelial cells (PMVECs) induces cell rounding but does not activate intracellular caspase-3/7 or cause cell death. ExoS and ExoT infection of epithelial cells leads to caspase-3/7 dependent cell death. Previous studies using epithelial cells show that ExoY alleviates the cytotoxic effects of ExoS and ExoT. Here, we sought to determine whether ExoY inhibits ExoS and ExoT induced caspase-3/7 activation and cell death in PMVECs.
Publication Date
5-2025
City
Mobile
Disciplines
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bacteriology | Genetics and Genomics | Immunology and Infectious Disease | Research Methods in Life Sciences | Respiratory Tract Diseases
Recommended Citation
Holm, Connor, "Pseudomonas aeruginosa ExoY Enzymatic Activity Inhibits ExoS-Induced Caspase-3/7 Activation but not Cytotoxicity in PMVECs" (2025). Poster Presentations. 44.
https://jagworks.southalabama.edu/honors_college_posters/44

Included in
Analytical, Diagnostic and Therapeutic Techniques and Equipment Commons, Bacteriology Commons, Genetics and Genomics Commons, Immunology and Infectious Disease Commons, Research Methods in Life Sciences Commons, Respiratory Tract Diseases Commons