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Cellular energy metabolism is complex, and NAD, or nicotinamide adenine dinucleotide, plays a huge role as an organic redox cofactor, driving metabolic reactions. The abundance of pathways dependent on NAD has led to an increase in the studies of NAD and its precursors. As a result, NR, or nicotinamide riboside, is now a popular nutraceutical taken to increase levels of NAD in the body. NR is a precursor to NAD inside cells. Metabolites with the same molecular formula as NR are found in urine and blood. Yet, NR is usually associated with these species in extracellular regions although NR is not stable extracellularly. Therefore, it is important to establish whether these metabolites could be species other than NR when studying NAD metabolism and turnover. Such isomers of NR include the three isomers of the 2’-deoxy-PYR series, also known as the 2’-deoxy-pyridone ribosides. These could be the extracellular species that are mistaken for NR. The 2’-deoxy-PYR are proposed to be byproducts of the hyper-oxidation of NAD. Although the 2’-deoxy-PYR molecules can be envisaged as derivatives of the known naturally occurring the 2 ,4, and 6 isomers of the pyridone ribosides PYR series, these deoxy-riboside species have never been synthesized. Due to the molecule's structure, it is hypothesized that it could be a substrate for DNA polymerases, possibly introducing mutations into healthy DNA. Because they are potentially biologically relevant, to test if these species are present in biological specimens, the synthesis of these molecules are of the utmost importance.

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Chemicals and Drugs

Investigation and Synthesis of 2-deoxy-PYR(MP)