Undergraduate Honors Theses
Date of Award
2021
Document Type
Undergraduate Thesis
Degree Name
BS
Department
Biomedical Sciences
Faculty Mentor
David Weber
Abstract
The purpose of the project presented in this thesis is to assess the contribution of inflammasome activation in mediating vascular wall remodeling that occurs following carotid artery injury due to decreased blood flow. To examine this, we used a mouse model of carotid artery ligation in mice lacking the expression of a key mediator of the inflammasome signaling pathway. Following ligation, we completed a histological assessment to compare the degree of the neointima formation and expression of inflammasome related proteins in both injured and the non-injured contralateral carotid artery in both wild-type (WT) and Caspase 1 knockout mice (Cas1 -/-).
Recommended Citation
Amadi, Ted, "The Role of Inflammasome in Vascular Remodeling Following Injury" (2021). Undergraduate Honors Theses. 2.
https://jagworks.southalabama.edu/honors_college_theses/2