Evaluating the Interaction Between Neu1-HER2 on the Expression of Fatty Acid Binding Protein 5 in MDA-MB-453 Cells

Authors

• Priscilla Foster, University of South AlabamaFollow

Files

Description

Breast cancer is at the forefront of cancer deaths among women. Understanding the underlying mechanisms that drive its progression is the key to creating targeted therapies. A specific receptor tyrosine kinase, HER2, activated by heregulin (HRG), promotes breast cancer cell growth and development. This growth factor receptor is sialylated, and desialylation of HER2 causes autophosphorylation, which leads to activation of cellular signaling events. One of the oncogenes regulated by HER2 is FABP5, which is well known to increase resistance to retinoic acid-mediated growth suppression. The objective of this study is to understand the role of Neu1 on the activation of HER2 and the regulation of the downstream target, FABP5. Our results have demonstrated that blocking the activity of sialidase Neuraminidase 1 (Neu1) with oseltamivir phosphate (OP) in breast cancer cell line MDA-MB-453 suppresses HRG-mediated activation of HER2 and its downstream targeted oncogene, FABP5. Furthermore, silencing of the Neu1 protein with siRNA suppressed the phosphorylation of HER2 and reduced the protein expression of FABP5. Knowledge of the interaction between Neu1 and HER2 could reveal novel medical therapies against these types of aggressive breast cancer, potentially improving the effectiveness of treatment and patient health overall.

Publication Date

5-2026

Disciplines

Biological Phenomena, Cell Phenomena, and Immunity | Cells | Investigative Techniques | Medical Cell Biology | Oncology | Other Medical Sciences | Physiological Processes | Therapeutics | Women's Health

Recommended Citation

Foster, Priscilla, "Evaluating the Interaction Between Neu1-HER2 on the Expression of Fatty Acid Binding Protein 5 in MDA-MB-453 Cells" (2026). Poster Presentations. 58.
https://jagworks.southalabama.edu/honors_college_posters/58