Document Type
Article
Publication Title
American Journal of Physiology-Lung Cellular and Molecular Physiology
Abstract
Capillary endothelial cells possess a specialized metabolism necessary to adapt to the unique alveolar-capillary environment. Here, we highlight how endothelial metabolism preserves the integrity of the pulmonary circulation by controlling vascular permeability, defending against oxidative stress, facilitating rapid migration and angiogenesis in response to injury, and regulating the epigenetic landscape of endothelial cells. Recent reports on single-cell RNA-sequencing reveal subpopulations of pulmonary capillary endothelial cells with distinctive reparative capacities, which potentially offer new insight into their metabolic signature. Lastly, we discuss broad implications of pulmonary vascular metabolism on acute respiratory distress syndrome, touching on emerging findings of endotheliitis in coronavirus disease 2019 (COVID-19) lungs.
First Page
L358
Last Page
L376
DOI
10.1152/ajplung.00131.2021
Publication Date
Summer 8-2021
Department
College of Medicine
Recommended Citation
Stevens, Reece P., et al. "Endothelial metabolism in pulmonary vascular homeostasis and acute respiratory distress syndrome." American Journal of Physiology-Lung Cellular and Molecular Physiology 321.2 (2021): L358-L376.
Comments
Copyright © 2021 the American Physiological Society.
Please visit the publisher's website for any inquiries about this work or for downloadable files for tables and figures using the following link: https://doi.org/10.1152/ajplung.00131.2021